Initial double combination therapy with OPSUMIT and tadalafil led to significant improvements from baseline to Week 16 in cardiopulmonary haemodynamics (except reduction in mRAP is non-significant ), functional parameters, NT-proBNP and risk profile in newly diagnosed, treatment-naïve patients with PAH.1
 Sibton O, Cottin V, Canuet M, et al. initial combination therapy of macitentan and tadalafil in pulmonary arterial hypertension. Eur Respir J. 2020 Sep 3;56 (3):2000673.
 OPSUMIT Ministry of health approved leaflet 15/10/2018