Adjust SPRAVATO® dosing frequency to increase the likelihood of positive outcomes (i.e., decrease or maintaining of CGI-S score)1
* Remission defined as MADRS ≤ 12. Frequency of administration was assessed and adjusted depending on whether remission was achieved. For patients in remission, treatment frequency was either maintained every 2 weeks or decreased from 1 session per week to every 2 weeks. For patients not in remission, treatment frequency was either maintained at 1 session per week or increased from every 2 weeks to 1 session per week until next assessment.
MADRS, Montgomery–Åsberg Depression Rating Scal
1- Nijs M, Wajs E, Aluisio L, et al. Managing Esketamine Treatment Frequency Toward Successful Outcomes: Analysis of Phase 3 Data. Int J Neuropsychopharmacol. 2020; 23 (7) :426-433.